DD2, my little over achiever, has had severe reflux (silent variety) since early infancy. Neither Zantac nor Axid (in the same class of drugs) helped us much at all. We did better with Prevacid (a PPI), but not great. We have had the greatest success with Zegerid (Prilosec, another PPI), but had to buffer it with Tums Cherry Supreme and gas drops to help her keep it down. From what I recall, Reglan is more controversial due to side effects. I found the following sites to be very helpful:
www.infantreflux.org (you will find tremendous information on the site and message boards; Laura (hellbennt) is a moderator)
http://www.marci-kids.com/ (great information for infants with reflux; my pedi GI personally knew one of the doctors which was great; consulting via email, they assisted us with Zegerid dosage and buffering)
I actually do not know how we would have survived without these resources.