IDK, but I wonder if there are any systemic effects of a staph infection OR if something systemic is causing the staph infection. Like I said, IDK and I'm not trying to be alarmist. We've used bactroban for staph pimples in the diaper area with no problems. I asked the ped if there were any SE and she said it was very safe. Is his skin still pretty red? If it is a pain reaction, I wonder if there is some extra absorbtion of the medicine since the skin is so raw? Just throwing things out there. I agree that 1/4 cup bleach baths is great for staph and eczema.